Columbus is believed to have first recorded the use of spit tobacco Jean Nicot, for whom the key ingredient in tobacco (nicotine) is named, began experimenting with tobacco seeds for medicinal purposes (1566 - sent snuff to Queen Catherine de Medici to treat her migraines) The "cure" was a dressing made of mashed tobacco leaves used to treat cuts, ringworm, asthma and migraine headaches Later, it's use expanded to include toothaches, ulcers and skin diseases First successful commercial crop was cultivated in Virginia in 1612 by Englishman John Rolfe - within 7 years, it was the colony's largest export |