Hepatitis B

Reporting Obligations

Individuals with suspect or confirmed cases must be reported to the Thunder Bay District Health Unit by the next working day by fax, phone or mail.

  • Fax: (807) 625-4822
  • Phone: 625-8318 or toll-free at 1-888-294—6630, ext. 8318
  • Mail: 999 Balmoral Street, Thunder Bay, ON P7B 6E7

Epidemiology

Aetiologic Agent:

Hepatitis B virus (HBV) is the causative agent. It is a DNA virus, composed of a nucleocapsid core (HBcAg), surrounded by an outer lipoprotein coat containing the surface antigen (HBsAg).

Clinical Presentation:

Acute hepatitis B infection is often not clinically apparent, with 50-70% of adult cases being asymptomatic. The onset of symptoms is usually insidious with anorexia, fatigue, vague abdominial discomfort, joint pain, fever and jaundice; many cases are asymptomatic.

Modes of transmission:

Via blood, blood products, saliva, CSF, pleural, peritoneal, semen and vaginal secretions and any other fluid containing blood.

Routes of transmission include:

• percutaneous, principally injection drug users: shared razors and toothbrushes have been implicated

• sexual: anal, vaginal, oral – men to women transmission is 3 times more efficient than that from women to men

• horizontal: household contacts

• vertical: mother to neonate

Incubation Period:

Usually 45-180 days, average 60-90 days. It may be as short as 2 weeks to the appearance of HBsAg and rarely as long as 6-9 months.

Period of Communicability:

All persons who are HBsAg positive are potentially infectious. Blood is infective many weeks before onset of first symptoms and remains infective through the acute period of disease and chronic period of disease. The younger an individual is when exposed to HBV infection, the more likely they will become a chronic carrier. Cases and carriers positive for HBeAg are known to be highly infectious. Chronic carriers can experience spikes in viremia over time, impacting infectivity.

 

Risk Factors/Susceptibility

All non-immune people are susceptible. Disease presentation is usually milder in children and may be asymptomatic in infants. Household transmission primarily occurs from child to child.

Risk factors:

• Injection drug use (IDU)

• Multiple heterosexual sex partners

• Men who have sex with men (MSM)

• Sex with HBV-infected individuals

• Hepatitis B carrier in family

• Blood transfusion; organ transplant

• Co-infection with another STI

• Dialysis recipient

• Invasive surgical/dental/ocular procedures abroad

• Tattoo/acupuncture/piercings

• Blood exposure

• Incarceration

 

Diagnosis & Laboratory Testing

Demonstration in sera of specific antigens and/or antibodies confirms diagnosis. For example:. Tests that will be performed for "Acute" Hepatitis B are HBsAg, HBcAb Total (IgG + IgM), HBcIgM -- will be performed only if HBcAb (IgG + IgM) Total is reactive. Tests that will be performed for "Chronic" Hepatitis B are HBsAg, HBcAb Total (IgG + IgM).

Testing Information & Requisition

 

Treatment & Case Management

Treatment is under the direction of the attending health care provider.

Acute cases of Hepatitis B should abstain from sexual contact or practice safer-sex until partners have been appropriately screened and/or immunized. Cases should not donate blood; occupational exposures should be managed according to the individual occupational protocols.

Hepatitis B immunization should be routinely offered to the risk groups (if not previously immunized) listed in the 'Publicly Funded Immunization Schedules for Ontario (December 2016)'.

The patient is eligible for free Hepatitis A vaccine. Household and sexual contacts are eligible for free Hepatitis B vaccine. To order, please use the appropriate vaccine order form; hepatitis A or hepatitis B.

 

Patient Information

Patient Fact Sheet

References

  1. Ministry of Health and Long Term Care, Infectious Diseases Protocol, 2016.  Appendix A (2014) and Appendix B (2014)
  2. PHAC, Primary Care Management of Hepatitis B—Quick Reference (HBV-QR).
  3. Heymann, D.L., Control of Communicable Disease Manual 20th Ed.), Washington, American Public Health Association, 2015.

 

Additional Resources

1. OHA. "Blood-Borne Diseases Surveillance Protocol for Ontario Hospitals."

2. PHAC. "Primary Care Management of Hepatitis B—Quick Reference (HBV-QR)."

3. MOHLTC. "Publicly Funded Immunization Schedule for Ontario", December 2016.

4. PHAC. "Canadian Immunization Guide, Hepatitis B Vaccine."

5. PHAC Fact Sheet

Last Updated: 26/10/2017